Effect of Artemisiae Argyi Folium Extract on Alcohol-Induced Gastritis

Objective: Alcohol is known to cause inflammation in the stomach by decreasing protective substances of gastric mucosa and increasing oxidative stress. The purpose this study was investigate anti-inflammatory effect Artemisiae Argyi Folium extract (AF) on alcohol-induced gastritis.Methods: total polyphenol flavonoid contents AF were confirmed through an vitro experiment. Radical scavenging activities using DPPH ABTS assays. In vivo experiments conducted mice divided into 5 groups (n=8): a normal group (Nor), gastritis (Con), administered 10 mg/kg sucralfate (SC), 100 (AFL), 200 AF(AFH). serum levels reactive oxygen species (ROS) determined, protein expressions tissues.Results: gastritis, alleviated damage caused alcohol. also decreased ROS levels. Western blots showed that expression NADPH oxidase NF-κB pathway associated with inflammation. adhesion molecules chemokine proteins, increased proteins.Conclusions: not only reduced stress but it relieved mucosal regulating pathway.